Environmental factors linked to hospitalizations in young children due to acute viral lower respiratory tract infections: a two-way case-crossover study


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Approx Res. April 18, 2022:113319. doi: 10.1016/j.envres.2022.113319. Online ahead of print.


OBJECTIVE: This study assessed the association of short-term exposure to environmental factors (relative humidity, temperature, NO2SO2O3PMtenand CO) with hospitalizations due to acute viral lower respiratory infections (ALRI) in children younger than two years before the era of COVID-19.

METHODS: We performed a two-way case-crossover study in 30,445 children with ALRI under two years of age in the Spanish Minimum Basic Dataset (MBDS) from 2013 to 2015. Environmental data were obtained from the Spanish National Meteorological Agency (AEMET). The association was assessed by conditional logistic regression.

RESULTS: Lower temperature one week before the day of the event (hospital admission) (q value = 0.012) and higher relative humidity one week (q value = 0.003) and two weeks (q value2 levels two weeks before the event were associated with hospital admissions (q value 2 (compared to latency time of 1 week (q value = 0.026) and 2 weeks (q value 3 (compared to latency time of 3 days (q-valueten (compared to a 2 week lag (q value

CONCLUSION: Short-term exposure to environmental factors (climatic conditions and ambient air contaminants) was linked to a higher likelihood of hospital admissions due to ARI. Our findings underscore the importance of monitoring environmental factors for assessing the likelihood of ALRI hospital admissions and planning public health resources.

PMID:35447151 | DOI:10.1016/j.envres.2022.113319


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