PFAS Collection 2022 | Environmental Health Perspectives



Per- and polyfluoroalkyl substances and risk of myocardial infarction and stroke: a nested case-control study in Sweden

PFAS have been linked to high cholesterol in some studies, potentially increasing the risk of cardiovascular disease. Schillemans et al. improved our knowledge of potential myocardial infarctions or strokes related to PFAS exposure.

Prenatal exposure to per- and polyfluoroalkyl substances and facial features at age 5 years: a study of the Danish national birth cohort

Certain craniofacial characteristics in children have been linked to fetal brain development. Luo et al. assessed three novel craniofacial features at age 5 that may signify alterations in the developing brain and their relationship to PFAS exposure in utero.

Related guest point of view
Using facial features as an endophenotypic marker of sensitivity to environmental exposures (Lyall)

Prenatal exposure to per- and polyfluoroalkyl substances and child growth trajectories during the first two years

Gao et al. investigated the links between PFAS exposure and growth trajectories during the first two years of life. Their research provided insight into the complex associations between PFAS exposure and offspring growth, including sexually dimorphic effects.

Gestational exposure to perfluoroalkyl substances and DNA methylation at birth and 12 years of age: a longitudinal epigenome-wide association study

Alterations in DNA methylation may underlie associations between prenatal exposure to PFAS and health outcomes later in life. Liu et al. assessed DNA methylation on genes linked to cancers, cognitive health, cardiovascular disease and kidney function.


Photograph of a teenage girlExposure to perfluoroalkyl substances and glucose homeostasis in young people

Goodrich et al. assessed the role of PFAS in type 2 diabetes in overweight adolescents. They demonstrated that sex dimorphism factors may be involved in PFAS-associated glucose dysregulation.

Maternal levels of perfluoroalkyl substances (PFAS) in early pregnancy in relation to preeclampsia subtypes and biomarkers of preeclampsia risk

Exposure to PFAS during pregnancy has been associated with numerous pregnancy complications, including preeclampsia. Bommarito et al. describes why assessing the heterogeneity of clinical preeclampsia subtypes may be important in PFAS studies.

Related scientific selection
A more specific objective: to clarify the PFAS-preeclampsia association by analyzing disease subtypes

Associations of Maternal Serum Perfluoroalkyl Substances Concentrations with Mineral Content and Bone Density in Young Adolescents: A Health Outcomes and Environmental Measures (HOME) Study

Decreased bone accumulation and strength have been linked to exposure to PFAS in early adolescence. Buckley et al. describes how this association may be modified by gender and lean body mass.

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A measure of strength: Developmental exposures to PFAS and bone mineral content in adolescence

Development of a physiologically-based pregnancy and lactation (PBPK) pharmacokinetic model for perfluorooctane sulfonate (PFOS) in rats and humans and its implications in deriving health-based toxicity values

Transplacental and lactational exposures to PFOS can lead to developmental and reproductive toxicity. Cabbage and Flax developed a new model to account for renal reabsorption and excretion during gestation and lactation to aid in PFOS risk assessment.


Image of a glass of waterMeasurement of new PFAS associated with drinking water in the blood of adults and children in Wilmington, North Carolina

Kotlarz et al. studied PFAS levels in residents near the Cape Fear River, which was contaminated by a fluorochemical plant. They highlighted the need to assess understudied fluoroethers that could account for a significant percentage of GenX exposure.

Maternal plasma perfluoroalkyl substances and miscarriage: a nested case-control study in the Danish national birth cohort

The etiology of pregnancy complications is complex. In a nested case-control study, Lyew et al. highlighted the need to understand the confounding role of reproductive history in studies assessing PFAS exposure and miscarriage.

Related scientific selection
PFAS and miscarriage in humans: expanding a sparse evidence base

Early exposure to perfluoroalkyl substances (PFAS) and ADHD: a meta-analysis of nine European population-based studies

Forns et al. extrapolated children’s exposures to PFASs from measured prenatal serum levels to study their relationship with ADHD. They highlighted the need to consider medical history and sociodemographic factors when evaluating neurobehavioral outcomes related to PFAS.

Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardiometabolic Indicators in Newborns: The Healthy Start Study

DNA alterations are associated with a variety of health phenotypes, including cardio-metabolic diseases. Starling et al. highlighted the need to study PFAS-related DNA methylation and potential associations with offspring growth, metabolism, and immune function.

Serum perfluoroalkyl substances, vaccine responses and morbidity in a cohort of children from Guinea-Bissau

Interactions between drug efficacy and environmental exposures have been largely unstudied. Timmerman et al. focused on understanding how PFAS, which are potential immunotoxicants, can reduce vaccine efficacy and increase morbidity.


Image of a greasy slice of pizzaFood as a source of exposure to environmental contaminants for pregnant women and children in six European countries

Understanding the pathways of exposure to PFAS is an integral part of developing a health protection policy. In the European multi-country Human Early Life Exposome study, Papadopoulou et al. assessed dietary intake to identify foods associated with increased levels of PFAS.

Contributions of Tap Water to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a National Prospective Cohort of U.S. Women

Drinking water is a known source of exposure to PFAS. Using modeling techniques, Hu et al. estimated the amount of serum PFAS attributable to tap water consumption.

Plasma levels of per- and polyfluoroalkyl substances and bone mineral density in middle childhood: a cross-sectional study (Project Viva, USA)

Clett et al. describes how exposure to PFAS can alter bone accumulation in middle childhood – and thus, potentially, peak bone mass in young adults, which is an important determinant of skeletal health throughout life. life.

Related scientific selection
Reduced bone mineral density in children: another potential health effect of PFAS

Exposure to perfluoroalkyl substances during fetal life and pubertal development in boys and girls from the Danish National Birth Cohort

Endocrine-disrupting chemicals, including PFAS, can alter hormone-mediated maturation. Ernest et al. assessed sex-specific associations of impaired pubertal development related to prenatal exposure to PFAS in a Danish population-based cohort.

Perfluoroalkyl substances and maternal thyroid hormones in early pregnancy: results from the Danish national birth cohort

Alterations in maternal thyroid hormones during pregnancy can alter fetal development. Inoue et al. assessed week-specific fluctuations of thyroid-stimulating hormone and free thyroxine during pregnancy in a Danish birth cohort.


Image of young pregnant woman lying on sofaConcentrations of per- and polyfluoroalkyl substances in maternal plasma in early pregnancy and maternal and neonatal thyroid function in a prospective birth cohort: Viva project (USA)

Maternal environmental exposures during pregnancy can have serious implications for maternal and neonatal health. Preston et al. highlighted how prenatal exposure to PFAS can influence thyroid function in mothers and infants.

Prenatal exposure to perfluoroalkyl substances and IQ scores at age 5: a study in the Danish national birth cohort

Prenatal exposure to PFASs has been implicated in neurocognitive and neurobehavioral development in children. Lyew et al. highlighted the need to examine PFAS exposure and cognitive and neuropsychiatric functional measures at multiple early childhood ages.

Maternal prenatal serum concentrations of per- and polyfluoroalkyl substances in association with autism spectrum disorders and intellectual disability

Many neurodevelopmental disorders are believed to derive in part from environmental exposures. In a case-control cohort in California, Lyal et al. assessed the role of prenatal exposure to PFASs in autism spectrum disorders and intellectual disability.

Plasma concentrations of perfluoroalkyl substances and risk of type 2 diabetes: a prospective survey of American women

Sun et al. highlighted the need to assess low-level PFAS exposure and its relationship to the risk of type 2 diabetes. Understanding any potential diabetogenic role of PFAS is critical to reducing the risk of disease development and exacerbation .

Images, top to bottom: heart: © iStockphoto/artoleshko; teenager: © iStockphoto/Vladimir Vladimirov; water: © iStockphoto/Besiki Kavtaradze; pizza: © onajourney/Shutterstock; pregnant woman: © iStockphoto/monkeybusinessimages.

Last updated on June 24, 2022


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